Invasive interventions are associated with substantially large placebo effects

Route of Placebo Administration: Robust Placebo Effects in Laboratory and Clinical Settings. Tao Liu. Neuroscience & Biobehavioral Reviews, https://doi.org/10.1016/j.neubiorev.2017.09.018

Highlights
•    Pivotal role of placebo administration in subsequent placebo responses.
•    Robust placebo analgesia in the context of anticipating an upcoming pain.
•    Enhanced placebo effects associated with invasive procedures

Abstract: Recent advances in laboratory and clinical research have greatly enhanced our understanding of placebo effects. However, little progress has been made in translational research that can well integrate these findings. This article examines pivotal role of placebo administration in subsequent placebo responses, providing a unified framework that accounts for robust placebo effects in both laboratory and clinical settings.

Keywords: placebo effects; placebo administration; route of administration; pain; pain anticipation; learning; conditioning; verbal suggestion; belief; reward expectation; appetitive motivation; emotion; anxiety; brain mechanisms; descending pain modulation; RCTs; invasive placebo; sham invasive procedure; acupuncture; clinical practice