We find that virtually all core assumptions and hypothesized mechanisms of posttraumatic stress disorder lack compelling or consistent empirical support

Posttraumatic stress disorder: An empirical evaluation of core assumptions. Gerald M.Rosen, Scott O. Lilienfeld. Clinical Psychology Review, Volume 28, Issue 5, June 2008, Pages 837-868, https://doi.org/10.1016/j.cpr.2007.12.002

Abstract: The diagnosis of posttraumatic stress disorder (PTSD) rests on several core assumptions, particularly the premise that a distinct class of traumatic events is linked to a distinct clinical syndrome. This core assumption of specific etiology ostensibly distinguishes the PTSD diagnosis from virtually all other psychiatric disorders. Additional attempts to distinguish PTSD from extant conditions have included searches for distinctive markers (e.g., biological and laboratory findings) and hypothesized underlying mechanisms (e.g., fragmentation of traumatic memory). We review the literature on PTSD's core assumptions and various attempts to validate the construct within a nomological network of distinctive correlates. We find that virtually all core assumptions and hypothesized mechanisms lack compelling or consistent empirical support. We consider the implications of these findings for conceptualizing PTSD in the forthcoming edition of the American Psychiatric Association's diagnostic manual.

Keywords: Posttraumatic stress disorder (PTSD); Validity; Construct validity; Discriminant validity; Traumatic events;Criterion A; Symptom criteria