Wednesday, September 30, 2020

We are all chimeric beings

We are all chimeric beings. Inspired by Rolf Degen, https://twitter.com/DegenRolf/status/1311007544081633287: Remaining cells from a previous fetus can lead to spooky actions in the mother's body


From the book he referenced to, David Linden's Unique: The New Science of Human Individuality > Fetomaternal cell trafficking: a story that begins with prenatal diagnosis and may end with stem cell therapy. Diana W. Bianchi. Journal of Pediatric Surgery (2007) 42, 12 – 18. https://nexthumanproject.com/references/Fetomaternal_Cell_Trafficking_JPS.pdf

Conclusive evidence that cells from a terminated fetus can persist in the mother and differentiate into cells in the mature organ came from the following study by Johnson et al [31], published in the journal Hepatology in 2002. In this study we received liver biopsy material from a woman with hepatitis C. She was a control subject for a study in which we were analyzing the association between fetal cell microchimerism and primary biliary cirrhosis. This woman had a history of having had one son, who was then 18 years old. Using X and Y chromosome–specific probes, we demonstrated that part of her liver contained entirely female (XX) cells, yet another part of her liver contained thousands of cells that were male (XY). We were able to obtain enough cells to isolate DNA and perform PCR amplification of short tandem repeat (STR) sequences. The DNA in the male part of the liver and the female part of the liver appeared related to each other, in that they each shared an allele at each locus tested. However, the STRs in the woman’s son’s DNA did not match the STRs in the male DNA in the liver. We were disappointed to conclude that the male cells in her liver could not originate from her son. However, after requesting and receiving a more detailed reproductive history, we realized that this woman had had 4 additional pregnancies, including 2 elective terminations and 2 miscarriages. We were subsequently able to obtain genomic DNA from 2 of the fathers of her noncompleted pregnancies. One of the fathers appeared to be a biological match for the male cells in the liver. We hypothesized, but can never prove, that these fetal cells originated from an elective termination of pregnancy that had been fathered by the man whose DNA we tested. Thus, in one woman, cells from a fetus that was terminated 17 to 19 years earlier remained for a long time in her body. We hypothesize that these fetal cells survived, migrated to her liver, which was a clinically diseased organ, and repopulated a significant portion of her liver. Interestingly, she did well clinically despite not taking her medications and not complying with medical care [31].


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