Drug and alcohol use is associated with risky sexual behavior, but they are not the cause of this riskiness

Etiological Overlap Between Sex Under the Influence and Number of Lifetime Sexual Partners. Brooke M. Huibregtse, Alexander S. Hatoum, Robin P. Corley, Sally Ann Rhea, John K. Hewitt & Michael C. Stallings. Behavior Genetics, Oct 28 2020. https://link.springer.com/article/10.1007/s10519-020-10019-7

Rolf Degen's take: https://twitter.com/DegenRolf/status/1321701607248199680

Abstract: Drug and alcohol use is associated with risky sexual behavior (RSB). It is unclear whether this association is due to correlated liabilities (e.g., third variables influencing both traits), or whether use of drugs and alcohol during sexual decision making increases RSB. This study addresses this question by fitting a series of biometrical models using over 800 twin pairs assessed in early adulthood (m = 25.21 years). Measures included an index of sex under the influence (e.g., frequency that drugs or alcohol affect sexual decision making), number of lifetime sexual partners, and a general measure of substance use. Analyses suggest the covariance among these measures is explained by both genetic and environmental correlated liabilities. The overlap was not specific to sex under the influence, but was shared with a measure of general substance use. Models testing necessary but not sufficient parameters for direction of causation suggest that sex under the influence is unlikely to cause an increase in RSB; more evidence for reverse causation was found.