Alcohol conditioned contexts enhance positive subjective alcohol effects and consumption

Alcohol conditioned contexts enhance positive subjective alcohol effects and consumption. Joseph A. Lutz, Emma Childs. Behavioural Processes, February 3 2021, 104340. https://doi.org/10.1016/j.beproc.2021.104340

Highlights

• Alcohol-paired environments enhanced positive subjective responses to alcohol.

• Alcohol-paired environments promoted alcohol drinking.

• Conditioning strength predicted early drinking in a context-dependent manner.

• Human CPP is a viable model to study alcohol environment associations.

• This approach may reveal the mechanisms by which contexts induce drinking.

• The model may be used to test strategies to prevent context-induced drinking.

Abstract: Associations between alcohol and the places it is consumed are important at all stages of alcohol abuse and addiction. However, it is not clear how the associations are formed in humans or how they influence drinking, and there are few effective strategies to prevent their pathological effects on alcohol use. We used a human laboratory model to study the effects of alcohol environments on alcohol consumption. Healthy regular binge drinkers completed conditioned place preference (CPP) with 0 vs. 80 mg/100 ml alcohol (Paired Group). Control participants (Unpaired Group) completed sessions without explicit alcohol-room pairings. After conditioning, participants completed alcohol self-administration in either the alcohol- or no alcohol-paired room. Paired group participants reported greater subjective stimulation and euphoria, and consumed more alcohol in the alcohol-paired room in comparison to the no alcohol-paired room, and controls tested in either room. Moreover, the strength of conditioning significantly predicted drinking; participants who exhibited the strongest CPP consumed the most alcohol in the alcohol-paired room. This is the first empirical evidence that laboratory-conditioned alcohol environments directly influence drinking. The results also confirm the viability of the model to examine the mechanisms by which alcohol environments stimulate drinking and to test strategies to counteract their influence on behavior.

Abbreviations: CPPconditioned place preferenceALC80mg alcohol/100ml bloodNo ALC0mg alcohol/100ml bloodBrACbreath alcohol concentrationHRheart rateBPblood pressure

Keywords: Alcoholconditioned place preferencecontextcueshumanself-administration