Gender Differences in the Intention to Get Vaccinated against COVID-19 - a Systematic Review and Meta-Analysis

Zintel, Stephanie and Flock, Charlotte and Arbogast, Anna Lisa and Forster, Alice and von Wagner, Christian and Sieverding, Monika, Gender Differences in the Intention to Get Vaccinated against COVID-19 - a Systematic Review and Meta-Analysis (March 12, 2021). SSRN: http://dx.doi.org/10.2139/ssrn.3803323

Abstract

Introduction: Since the end of 2020, the first officially approved vaccines against COVID-19 are available and vaccination roll out has started worldwide. As high vaccination rates are necessary to reach herd immunity and overcome the pandemic, it is important to identify sociodemographic characteristics that are associated with vaccination intention or hesitancy. The goal of our review was to analyze whether there are gender differences in the intention to get vaccinated against COVID-19.

Method: We conducted a systematic review and meta-analytical calculations to analyze gender differences in the COVID-19 vaccination intention. PubMed, Web of Science and PsycInfo were repeatedly searched between November 19th 2020 and January 7th 2021 for studies reporting absolute frequencies in COVID-19 vaccination intention separated by gender or statistical tests for gender differences. A quality appraisal was conducted and averaged odds ratios comparing vaccine intenders among men and women were computed via meta-analyses.

Results: Sixty studies were included in the review and data for 46 studies were available for meta-analytic computations. A majority (58.3%) of papers reported men to have higher intentions to get the COVID-19 vaccine. Meta-analytic calculations of 46 studies (n = 141 550) showed that significantly more men stated that they would get vaccinated, OR of 1.41 (95% CI: 1.28 to 1.55 respectively). Findings suggest that this effect is evident in several countries around the world and that the difference is bigger in samples of health care workers than in unspecified general population samples.

Conclusion: This systematic review and meta-analysis provides evidence that men are more willing to have the COVID-19 vaccine. The reasons for the lower vaccination intentions of women should be investigated and addressed. Heterogeneity of data and representativeness of samples have to be considered when interpreting the results.

Keywords: COVID-19, vaccination, intention, gender differences, health care workers, systematic review, meta-analysis