Male brain type women and female brain type men: Gender atypical cognitive profiles and their correlates. Annika M., Svedholm-Häkkinen, Sini J. Ojala, & Marjaana Lindeman. Personality and Individual Differences, Volume 122, February 1 2018, Pages 7–12. https://doi.org/10.1016/j.paid.2017.09.041
Highlights
• Sex differences have been documented in occupations, interests, and abilities
• Empathizing-Systemizing theory attempts to explain cognitive sex differences
• Women on average empathize more, men on average systemize more
• We studied men and women with gender atypical cognitive profiles
• Gender atypical profiles predicted qualities commonly linked with the opposite sex
Abstract: Gender differences exist in abilities, interests, and occupations. According to the Empathizing-Systemizing theory, the reason for all gender differences lies in the relative weights of two cognitive processes: women empathize more, which is useful in understanding people, while men systemize more, which means interpreting phenomena as rule-based systems. The terms “male and female brain type” refer to a heightened preference for one process over the other. We aimed to find out whether the gender atypical groups of male brain type women and female brain type men are more similar to the opposite sex than to their own in terms of a range of social, cognitive and personality variables. Female and male brain type groups were identified and compared within both genders in an online study (N = 2983). The results show there are female brain type men and male brain type women, who are characterized by qualities more often associated with the opposite sex, and who have not been reached by prior research. Thus, these findings demonstrate that cognitive type is a more powerful predictor of certain characteristics than is biological sex.
Keywords: Brain type; Empathizing; Systemizing; Cognitive style; Gender differences
Friday, October 6, 2017
Participants who read about an underdog had higher creativity scores and produced a wider range of ideas
The Underdog Advantage in Creativity. Abby Boytos, Kerry Smith, and JongHan Kim. Thinking Skills and Creativity, https://doi.org/10.1016/j.tsc.2017.10.003
Highlights
• The study examines how thinking about underdogs can enhance creativity.
• Underdogs often achieve success by finding creative solutions.
• For underdogs, their approach motivation and lack of resources give underdogs a creative advantage.
• Reading an underdog story may predispose the individual to finding creative solutions.
Abstract: Underdogs are expected to lose. Yet, many underdogs—from the Biblical David to today’s Harry Potter—emerge victorious. What do underdogs who win against seemingly impossible odds have in common? One answer may be creativity: they find creative ways to reach their goals. To determine how creativity figures into the success of underdogs, we randomly assigned participants in this study to either of two groups: one that reads a story about an underdog and one that reads a story about a top dog. After reading their respective stories, the participants completed the Torrance Tests of Creative Thinking. As we predicted, participants who had read about an underdog had higher creativity scores and produced a wider range of ideas than those who had read about a top dog. Those results suggested that their contemplation of successful underdogs had stimulated the participants’ creativity. The implication is that the underdog experience may itself predispose individuals to finding creative solutions.
Keywords: creativity; underdog; top dog; inspiration; carryover effect
Highlights
• The study examines how thinking about underdogs can enhance creativity.
• Underdogs often achieve success by finding creative solutions.
• For underdogs, their approach motivation and lack of resources give underdogs a creative advantage.
• Reading an underdog story may predispose the individual to finding creative solutions.
Abstract: Underdogs are expected to lose. Yet, many underdogs—from the Biblical David to today’s Harry Potter—emerge victorious. What do underdogs who win against seemingly impossible odds have in common? One answer may be creativity: they find creative ways to reach their goals. To determine how creativity figures into the success of underdogs, we randomly assigned participants in this study to either of two groups: one that reads a story about an underdog and one that reads a story about a top dog. After reading their respective stories, the participants completed the Torrance Tests of Creative Thinking. As we predicted, participants who had read about an underdog had higher creativity scores and produced a wider range of ideas than those who had read about a top dog. Those results suggested that their contemplation of successful underdogs had stimulated the participants’ creativity. The implication is that the underdog experience may itself predispose individuals to finding creative solutions.
Keywords: creativity; underdog; top dog; inspiration; carryover effect
Educational differences in the chances and timing of grandparenthood
Who becomes a grandparent – and when? Educational differences in the chances and timing of grandparenthood. Jan Skopek and Thomas Leopold. Demographic Research, Vol 37, article 29, pages 917-928. http://www.demographic-research.org/Volumes/Vol37/29/
Abstract
BACKGROUND: Despite recent advances, the demographic understanding of grandparenthood remains limited.
OBJECTIVE: Our study examines educational differences in the transition to grandparenthood. Comparing East and West Germany, we analyze educational differences in a) the chance of becoming a grandparent, and b) the timing of grandparenthood for both men and women.
METHODS: We used fertility data across three family generations (German Ageing Survey, N= 2,434 men and women born 1933‒1948) and methods of survival time analysis to study educational gradients in the transition to grandparenthood.
RESULTS: We found a strong educational gradient in the chances of grandparenthood among West German women: Lower-educated women’s chances of becoming a grandmother were similar to higher-educated women’s chances of becoming a mother.
CONCLUSIONS: Our findings have implications for research on multi-generational social mobility and on the consequences of grandparenthood.
CONTRIBUTION: Our study is the first to analyze how the transition to grandparenthood is socially stratified.
Abstract
BACKGROUND: Despite recent advances, the demographic understanding of grandparenthood remains limited.
OBJECTIVE: Our study examines educational differences in the transition to grandparenthood. Comparing East and West Germany, we analyze educational differences in a) the chance of becoming a grandparent, and b) the timing of grandparenthood for both men and women.
METHODS: We used fertility data across three family generations (German Ageing Survey, N= 2,434 men and women born 1933‒1948) and methods of survival time analysis to study educational gradients in the transition to grandparenthood.
RESULTS: We found a strong educational gradient in the chances of grandparenthood among West German women: Lower-educated women’s chances of becoming a grandmother were similar to higher-educated women’s chances of becoming a mother.
CONCLUSIONS: Our findings have implications for research on multi-generational social mobility and on the consequences of grandparenthood.
CONTRIBUTION: Our study is the first to analyze how the transition to grandparenthood is socially stratified.
Thursday, October 5, 2017
The most common word during sleep is "No," 10pct of speech are profanities and 26pct are interrogations
What does the sleeping brain say? Syntax and semantics of sleep talking in healthy subjects and in parasomnia patients. Isabelle Arnulf et al. Sleep, zsx159, https://doi.org/10.1093/sleep/zsx159
Abstract
Objectives: Speech is a complex function in humans, but the linguistic characteristics of sleep talking are unknown. We analyzed sleep-associated speech in adults, mostly (92%) during parasomnias.
Methods: The utterances recorded during night-time video-polysomnography were analyzed for number of words, propositions and speech episodes, frequency, gaps and pauses (denoting turn-taking in the conversation), lemmatization, verbosity, negative/imperative/interrogative tone, first/second person, politeness and abuse.
Results: The 232 subjects (aged 49.5 ± 20 y old; 41% women; 129 with rapid eye movement [REM] sleep behavior disorder and 87 with sleepwalking/sleep terrors, 15 healthy subjects and 1 patient with sleep apnea speaking in non-REM sleep) uttered 882 speech episodes, containing 59% non-verbal utterance (mumbles, shouts, whispers, laughs) and 3349 understandable words. The most frequent word was “No”: negations represented 21.4% of clauses (more in non-REM sleep). Interrogations were found in 26% of speech episodes (more in non-REM sleep), and subordinate clauses were found in 12.9% of speech episode. As many as 9.7% of clauses contained profanities (more in non-REM sleep). Verbal abuse lasted longer in REM sleep and was mostly directed towards insulting or condemning someone, whereas swearing predominated in non-REM sleep. Men sleep-talked more than women and used a higher proportion of profanities. Apparent turn-taking in the conversation respected the usual language gaps.
Conclusions: Sleep talking parallels awake talking for syntax, semantics and turn- taking in conversation, suggesting that the sleeping brain can function at a high level. Language during sleep is mostly a familiar, tensed conversation with inaudible others, suggestive of conflicts.
Keywords: sleep talking, language, syntax, linguistics, semantics, verbal abuse, REM sleep behavior disorder, sleepwalking
My comment: The most common word during sleep is "No," and 10pct of speech are profanities and 26pct are interrogations.
Abstract
Objectives: Speech is a complex function in humans, but the linguistic characteristics of sleep talking are unknown. We analyzed sleep-associated speech in adults, mostly (92%) during parasomnias.
Methods: The utterances recorded during night-time video-polysomnography were analyzed for number of words, propositions and speech episodes, frequency, gaps and pauses (denoting turn-taking in the conversation), lemmatization, verbosity, negative/imperative/interrogative tone, first/second person, politeness and abuse.
Results: The 232 subjects (aged 49.5 ± 20 y old; 41% women; 129 with rapid eye movement [REM] sleep behavior disorder and 87 with sleepwalking/sleep terrors, 15 healthy subjects and 1 patient with sleep apnea speaking in non-REM sleep) uttered 882 speech episodes, containing 59% non-verbal utterance (mumbles, shouts, whispers, laughs) and 3349 understandable words. The most frequent word was “No”: negations represented 21.4% of clauses (more in non-REM sleep). Interrogations were found in 26% of speech episodes (more in non-REM sleep), and subordinate clauses were found in 12.9% of speech episode. As many as 9.7% of clauses contained profanities (more in non-REM sleep). Verbal abuse lasted longer in REM sleep and was mostly directed towards insulting or condemning someone, whereas swearing predominated in non-REM sleep. Men sleep-talked more than women and used a higher proportion of profanities. Apparent turn-taking in the conversation respected the usual language gaps.
Conclusions: Sleep talking parallels awake talking for syntax, semantics and turn- taking in conversation, suggesting that the sleeping brain can function at a high level. Language during sleep is mostly a familiar, tensed conversation with inaudible others, suggestive of conflicts.
Keywords: sleep talking, language, syntax, linguistics, semantics, verbal abuse, REM sleep behavior disorder, sleepwalking
My comment: The most common word during sleep is "No," and 10pct of speech are profanities and 26pct are interrogations.
The End of Free College in England: Implications for Quality, Enrolments, and Equity
The End of Free College in England: Implications for Quality, Enrolments, and Equity. Richard Murphy, Judith Scott-Clayton, Gillian Wyness. NBER Working Paper No. 23888. www.nber.org/papers/w23888
Abstract: Despite increasing financial pressures on higher education systems throughout the world, many governments remain resolutely opposed to the introduction of tuition fees, and some countries and states where tuition fees have been long established are now reconsidering free higher education. This paper examines the consequences of charging tuition fees on university quality, enrolments, and equity. To do so, we study the English higher education system which has, in just two decades, moved from a free college system to one in which tuition fees are among the highest in the world. Our findings suggest that England’s shift has resulted in increased funding per head, rising enrolments, and a narrowing of the participation gap between advantaged and disadvantaged students. In contrast to other systems with high tuition fees, the English system is distinct in that its income-contingent loan system keeps university free at the point of entry, and provides students with comparatively generous assistance for living expenses. We conclude that tuition fees, at least in the English case supported their goals of increasing quality, quantity, and equity in higher education.
Abstract: Despite increasing financial pressures on higher education systems throughout the world, many governments remain resolutely opposed to the introduction of tuition fees, and some countries and states where tuition fees have been long established are now reconsidering free higher education. This paper examines the consequences of charging tuition fees on university quality, enrolments, and equity. To do so, we study the English higher education system which has, in just two decades, moved from a free college system to one in which tuition fees are among the highest in the world. Our findings suggest that England’s shift has resulted in increased funding per head, rising enrolments, and a narrowing of the participation gap between advantaged and disadvantaged students. In contrast to other systems with high tuition fees, the English system is distinct in that its income-contingent loan system keeps university free at the point of entry, and provides students with comparatively generous assistance for living expenses. We conclude that tuition fees, at least in the English case supported their goals of increasing quality, quantity, and equity in higher education.
Individual Difference Correlates of Self-Perceptions of Creativity
Individual Difference Correlates of Self-Perceptions of Creativity. Mark Batey and David J. Hughes. In book: The Creative Self, pp.185-218. DOI: 10.1016/B978-0-12-809790-8.00011-X
Abstract: The current chapter reports a systematic review of the relationship between self-perceptions of creativity and the individual difference traits of cognitive ability and personality. To structure our review, we separate out self-perceptions of creative traits, creative processes, and creative products. Our findings reveal that cognitive ability measures rarely relate to creative self-perceptions, but there are consistent positive associations with Openness to Experience and Extraversion. The relationships with Neuroticism, Agreeableness, and Conscientiousness are more nuanced and vary relative to the type of self-perception (trait, process, product), the domain of the self-perception (e.g., arts vs. science), or culture. We explore some of the likely theoretical rationales for the findings and identify areas in need of further research. Lastly, we present a series of hypothetical models outlining nuanced relations between self-perceptions and individual differences and we present an exploratory but explanatory model that situates individual differences, self-perceptions of creativity, and actual creative achievement.
Abstract: The current chapter reports a systematic review of the relationship between self-perceptions of creativity and the individual difference traits of cognitive ability and personality. To structure our review, we separate out self-perceptions of creative traits, creative processes, and creative products. Our findings reveal that cognitive ability measures rarely relate to creative self-perceptions, but there are consistent positive associations with Openness to Experience and Extraversion. The relationships with Neuroticism, Agreeableness, and Conscientiousness are more nuanced and vary relative to the type of self-perception (trait, process, product), the domain of the self-perception (e.g., arts vs. science), or culture. We explore some of the likely theoretical rationales for the findings and identify areas in need of further research. Lastly, we present a series of hypothetical models outlining nuanced relations between self-perceptions and individual differences and we present an exploratory but explanatory model that situates individual differences, self-perceptions of creativity, and actual creative achievement.
We feel with more intensity when observed
Janina Steinmetz and Stefan Pfattheicher (2017). Beyond Social Facilitation: A Review of the Far-Reaching Effects of Social Attention. Social Cognition: Vol. 35, No. 5, pp. 585-599. https://doi.org/10.1521/soco.2017.35.5.585
Abstract: Social psychology has demonstrated that people behave differently in social attention, compared to when alone. First and foremost, being in social attention affects people's performance and their interpersonal behavior by increasing arousal and reputational concerns, respectively. However, newer work demonstrates more fundamental intra-psychological effects of social attention. As mere reminders of social attention can activate reputational concerns, people's thoughts and behavior are affected by such reminders even when people's reputation is not at stake. These findings provide a deeper look at more intra-personal effects of social attention. As a result, recent research focuses on how social attention fundamentally influences people's subjective perceptions and experiences. In this review, we provide an overview of the far-reaching effects of social attention, identify relevant moderators and mediators, discuss socio-motivational and cognitive processes underlying these effects, and highlight avenues for future research.
KEYWORDS: social attention, social facilitation, shared reality, social presence
Abstract: Social psychology has demonstrated that people behave differently in social attention, compared to when alone. First and foremost, being in social attention affects people's performance and their interpersonal behavior by increasing arousal and reputational concerns, respectively. However, newer work demonstrates more fundamental intra-psychological effects of social attention. As mere reminders of social attention can activate reputational concerns, people's thoughts and behavior are affected by such reminders even when people's reputation is not at stake. These findings provide a deeper look at more intra-personal effects of social attention. As a result, recent research focuses on how social attention fundamentally influences people's subjective perceptions and experiences. In this review, we provide an overview of the far-reaching effects of social attention, identify relevant moderators and mediators, discuss socio-motivational and cognitive processes underlying these effects, and highlight avenues for future research.
KEYWORDS: social attention, social facilitation, shared reality, social presence
Macaques conceal food from alpha males by inhibiting interest in it, refraining from approaching it or looking at it
Factors influencing deceptive behaviours in Tonkean macaques (Macaca tonkeana). Charlotte Canteloup et al. https://doi.org/10.1163/1568539X-00003443
Abstract: The complex social environments of primates create opportunities for engaging in tactical deception, especially for subordinate individuals. We analysed the behaviour of subordinate Tonkean macaques with dominant conspecifics in an experimental food competition context. The subordinate macaque could see two pieces of food in a test area, but only one piece was visible to the dominant. Both individuals were released into the test area at the same time or with the subordinate given a short head start on the dominant. Here, based on video analysis of the subordinates’ behaviours, we describe and classify functionally deceptive behaviours displayed by subordinates, and report factors that influenced these behaviours. Subordinates used several types of tactical deception, including concealment and distraction, especially when paired with competitors of much higher social rank, and they obtained the hidden food more frequently when they used a combination of tactics rather than only one.
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The most frequently used tactic was concealment by inhibiting interest in object, either by refraining from approaching the food, or ‘freezing’ (see Video 1 in the online edition of this journal, which can be accessed via http://booksandjournals.brillonline.com/content/journals/1568539x), sometimes avoiding looking at the food. In this kind of concealment, subordinates acted as if they were unaware of the presence of food, for example by not entering the test area, or entering and then stopping or sitting down. The most parsimonious interpretation of this tactic is that the subordinate was simply inhibited by the dominant’s presence and/or gaze (behaviour reading hypothesis; e.g., Povinelli & Vonk, 2003), rather than actively refraining from approaching despite knowing that the dominant was unaware of the food (mindreading hypothesis; e.g., Call & Tomasello, 2008). It is conceivable that most cases of simple concealment by inhibiting interest reflect simple behavioural inhibition induced by the presence of a dominant competitor.
Concealment by inhibiting interest was used on its own or combined with other tactics such as concealment by hiding. In concealment by hiding, subordinates behaved so as not to be seen by the dominant. For example, they refrained from immediately entering the test area, or headed for the hidden food when the dominant’s back was turned (see Video 2 in the online edition of this journal, which can be accessed via http://booksandjournals. brillonline.com/content/journals/1568539x) or after the dominant left the test area. Similar behaviour has been described in the context of sneaky matings in long-tailed macaques (Macaca fascicularis: Overduin-de Vries et al., 2015), and geladas (Theropithecus gelada: le Roux et al., 2013), done out of view of the alpha male. We previously reported that subordinate Tonkean macaques moved preferentially for hidden food when released simultaneously or slightly before the dominant, and proposed that they are capable of visual perspective-taking (Canteloup et al., 2016). In this context, concealment by hiding could reflect an active attempt by subordinates to be out of view of the dominant. However, we cannot exclude the lower-level explanation that subordinates merely reacted to the dominant’s gaze, without perspective-taking (Canteloup et al., 2016).
Abstract: The complex social environments of primates create opportunities for engaging in tactical deception, especially for subordinate individuals. We analysed the behaviour of subordinate Tonkean macaques with dominant conspecifics in an experimental food competition context. The subordinate macaque could see two pieces of food in a test area, but only one piece was visible to the dominant. Both individuals were released into the test area at the same time or with the subordinate given a short head start on the dominant. Here, based on video analysis of the subordinates’ behaviours, we describe and classify functionally deceptive behaviours displayed by subordinates, and report factors that influenced these behaviours. Subordinates used several types of tactical deception, including concealment and distraction, especially when paired with competitors of much higher social rank, and they obtained the hidden food more frequently when they used a combination of tactics rather than only one.
---
The most frequently used tactic was concealment by inhibiting interest in object, either by refraining from approaching the food, or ‘freezing’ (see Video 1 in the online edition of this journal, which can be accessed via http://booksandjournals.brillonline.com/content/journals/1568539x), sometimes avoiding looking at the food. In this kind of concealment, subordinates acted as if they were unaware of the presence of food, for example by not entering the test area, or entering and then stopping or sitting down. The most parsimonious interpretation of this tactic is that the subordinate was simply inhibited by the dominant’s presence and/or gaze (behaviour reading hypothesis; e.g., Povinelli & Vonk, 2003), rather than actively refraining from approaching despite knowing that the dominant was unaware of the food (mindreading hypothesis; e.g., Call & Tomasello, 2008). It is conceivable that most cases of simple concealment by inhibiting interest reflect simple behavioural inhibition induced by the presence of a dominant competitor.
Concealment by inhibiting interest was used on its own or combined with other tactics such as concealment by hiding. In concealment by hiding, subordinates behaved so as not to be seen by the dominant. For example, they refrained from immediately entering the test area, or headed for the hidden food when the dominant’s back was turned (see Video 2 in the online edition of this journal, which can be accessed via http://booksandjournals. brillonline.com/content/journals/1568539x) or after the dominant left the test area. Similar behaviour has been described in the context of sneaky matings in long-tailed macaques (Macaca fascicularis: Overduin-de Vries et al., 2015), and geladas (Theropithecus gelada: le Roux et al., 2013), done out of view of the alpha male. We previously reported that subordinate Tonkean macaques moved preferentially for hidden food when released simultaneously or slightly before the dominant, and proposed that they are capable of visual perspective-taking (Canteloup et al., 2016). In this context, concealment by hiding could reflect an active attempt by subordinates to be out of view of the dominant. However, we cannot exclude the lower-level explanation that subordinates merely reacted to the dominant’s gaze, without perspective-taking (Canteloup et al., 2016).
Wednesday, October 4, 2017
Most cancer drugs entered the market without evidence of benefit on survival or quality of life
Availability of evidence of benefits on overall survival and quality of life of cancer drugs approved by European Medicines Agency: retrospective cohort study of drug approvals 2009-13. BMJ 2017; 359 doi: https://doi.org/10.1136/bmj.j4530
Abstract
Objective: To determine the availability of data on overall survival and quality of life benefits of cancer drugs approved in Europe.
Design: Retrospective cohort study.
Setting: Publicly accessible regulatory and scientific reports on cancer approvals by the European Medicines Agency (EMA) from 2009 to 2013.
Main outcome measures: Pivotal and postmarketing trials of cancer drugs according to their design features (randomisation, crossover, blinding), comparators, and endpoints. Availability and magnitude of benefit on overall survival or quality of life determined at time of approval and after market entry. Validated European Society for Medical Oncology Magnitude of Clinical Benefit Scale (ESMO-MCBS) used to assess the clinical value of the reported gains in published studies of cancer drugs.
Results: From 2009 to 2013, the EMA approved the use of 48 cancer drugs for 68 indications. Of these, eight indications (12%) were approved on the basis of a single arm study. At the time of market approval, there was significant prolongation of survival in 24 of the 68 (35%). The magnitude of the benefit on overall survival ranged from 1.0 to 5.8 months (median 2.7 months). At the time of market approval, there was an improvement in quality of life in seven of 68 indications (10%). Out of 44 indications for which there was no evidence of a survival gain at the time of market authorisation, in the subsequent postmarketing period there was evidence for extension of life in three (7%) and reported benefit on quality of life in five (11%). Of the 68 cancer indications with EMA approval, and with a median of 5.4 years’ follow-up (minimum 3.3 years, maximum 8.1 years), only 35 (51%) had shown a significant improvement in survival or quality of life, while 33 (49%) remained uncertain. Of 23 indications associated with a survival benefit that could be scored with the ESMO-MCBS tool, the benefit was judged to be clinically meaningful in less than half (11/23, 48%).
Conclusions: This systematic evaluation of oncology approvals by the EMA in 2009-13 shows that most drugs entered the market without evidence of benefit on survival or quality of life. At a minimum of 3.3 years after market entry, there was still no conclusive evidence that these drugs either extended or improved life for most cancer indications. When there were survival gains over existing treatment options or placebo, they were often marginal.
My commentary: My thesis of why this came to pass is that our desperation for cancer death is so great that a few months of life and the hope of maybe, perhaps, having the cure in your hands, are enough to make us suffer those treatments and for doctors to try them
Abstract
Objective: To determine the availability of data on overall survival and quality of life benefits of cancer drugs approved in Europe.
Design: Retrospective cohort study.
Setting: Publicly accessible regulatory and scientific reports on cancer approvals by the European Medicines Agency (EMA) from 2009 to 2013.
Main outcome measures: Pivotal and postmarketing trials of cancer drugs according to their design features (randomisation, crossover, blinding), comparators, and endpoints. Availability and magnitude of benefit on overall survival or quality of life determined at time of approval and after market entry. Validated European Society for Medical Oncology Magnitude of Clinical Benefit Scale (ESMO-MCBS) used to assess the clinical value of the reported gains in published studies of cancer drugs.
Results: From 2009 to 2013, the EMA approved the use of 48 cancer drugs for 68 indications. Of these, eight indications (12%) were approved on the basis of a single arm study. At the time of market approval, there was significant prolongation of survival in 24 of the 68 (35%). The magnitude of the benefit on overall survival ranged from 1.0 to 5.8 months (median 2.7 months). At the time of market approval, there was an improvement in quality of life in seven of 68 indications (10%). Out of 44 indications for which there was no evidence of a survival gain at the time of market authorisation, in the subsequent postmarketing period there was evidence for extension of life in three (7%) and reported benefit on quality of life in five (11%). Of the 68 cancer indications with EMA approval, and with a median of 5.4 years’ follow-up (minimum 3.3 years, maximum 8.1 years), only 35 (51%) had shown a significant improvement in survival or quality of life, while 33 (49%) remained uncertain. Of 23 indications associated with a survival benefit that could be scored with the ESMO-MCBS tool, the benefit was judged to be clinically meaningful in less than half (11/23, 48%).
Conclusions: This systematic evaluation of oncology approvals by the EMA in 2009-13 shows that most drugs entered the market without evidence of benefit on survival or quality of life. At a minimum of 3.3 years after market entry, there was still no conclusive evidence that these drugs either extended or improved life for most cancer indications. When there were survival gains over existing treatment options or placebo, they were often marginal.
My commentary: My thesis of why this came to pass is that our desperation for cancer death is so great that a few months of life and the hope of maybe, perhaps, having the cure in your hands, are enough to make us suffer those treatments and for doctors to try them
Democrat veterans suffer more PTSD than Republicans -- Political Affiliation, Probable PTSD, and Symptoms of Depression in Veterans
Political Affiliation, Probable PTSD, and Symptoms of Depression in Iraq and Afghanistan Combat Veterans: A Pilot Study. Lating, Jeffrey M. et al. Journal of Nervous & Mental Disease: October 2017 - Volume 205 - Issue 10 - p 809–811. doi: 10.1097/NMD.0000000000000715
Abstract: Ideological commitment of military personnel has been associated with mitigating trauma and protecting mental health. This pilot study assessed whether Democratic and Republican political affiliation differentially predicted probable posttraumatic stress disorder (PTSD) and symptoms of depression in 62 male Iraq and Afghanistan combat veterans. The Liberalism-Conservatism Scale, the PTSD Checklist-Military Version (PCL-M), and the Patient Health Questionnaire–9 (PHQ-9) were assessment measures. Results revealed that Democratic combat veterans had stronger liberal attitudes than Republican combat veterans (r = 0.95). Moreover, of the 50% of the entire sample higher than the cutoff score of 50 on the PCL-M, 84.8% were Democrats compared with 10.3% of Republicans. On the PHQ-9, 46.9% of Democrats compared with 3.7% of Republicans were higher than the cutoff score of 20. These initial results suggest possible mechanisms of action, including differences in shattered world view assumptions, willingness to disclose emotional concerns, and physiological reactions between Democratic and Republican combat veterans.
My commentary: It is just a pilot study, so we don't know how representative is. They say that Democrat veterans suffer more PTSD than Republicans. Explanations are: "The large effects sizes found in these data suggest the possibility worth exploring further that identified political affiliation might capture a shattered world view occurring more in Democrat than Republican combat veterans. Moreover, because Republicans are more likely than Democrats to report being in better mental health (Newport, 2007), it is possible that Democrats are more likely than Republicans to disclose emotional concerns, and thus more likely to complete these types of studies. In addition, there are data to suggest that there might be basic structural differences in the brains of those who identify as conservative or liberal (Oxley et al., 2008). Therefore, it might be worth investigating if these possible differences are related to the physiological diatheses associated with PTSD and depression (Elbejjani et al., 2015; Pitman et al., 2012)."
Abstract: Ideological commitment of military personnel has been associated with mitigating trauma and protecting mental health. This pilot study assessed whether Democratic and Republican political affiliation differentially predicted probable posttraumatic stress disorder (PTSD) and symptoms of depression in 62 male Iraq and Afghanistan combat veterans. The Liberalism-Conservatism Scale, the PTSD Checklist-Military Version (PCL-M), and the Patient Health Questionnaire–9 (PHQ-9) were assessment measures. Results revealed that Democratic combat veterans had stronger liberal attitudes than Republican combat veterans (r = 0.95). Moreover, of the 50% of the entire sample higher than the cutoff score of 50 on the PCL-M, 84.8% were Democrats compared with 10.3% of Republicans. On the PHQ-9, 46.9% of Democrats compared with 3.7% of Republicans were higher than the cutoff score of 20. These initial results suggest possible mechanisms of action, including differences in shattered world view assumptions, willingness to disclose emotional concerns, and physiological reactions between Democratic and Republican combat veterans.
My commentary: It is just a pilot study, so we don't know how representative is. They say that Democrat veterans suffer more PTSD than Republicans. Explanations are: "The large effects sizes found in these data suggest the possibility worth exploring further that identified political affiliation might capture a shattered world view occurring more in Democrat than Republican combat veterans. Moreover, because Republicans are more likely than Democrats to report being in better mental health (Newport, 2007), it is possible that Democrats are more likely than Republicans to disclose emotional concerns, and thus more likely to complete these types of studies. In addition, there are data to suggest that there might be basic structural differences in the brains of those who identify as conservative or liberal (Oxley et al., 2008). Therefore, it might be worth investigating if these possible differences are related to the physiological diatheses associated with PTSD and depression (Elbejjani et al., 2015; Pitman et al., 2012)."
Searching for Moral Dumbfounding: Identifying Measurable Indicators
McHugh, C., McGann, M., Igou, E. R., & Kinsella, E. L. (2017). Searching for Moral Dumbfounding: Identifying Measurable Indicators of Moral Dumbfounding. Collabra: Psychology, 3(1), 23. DOI: http://doi.org/10.1525/collabra.79
Abstract: Moral dumbfounding is defined as maintaining a moral judgement, without supporting reasons. The most cited demonstration of dumbfounding does not identify a specific measure of dumbfounding and has not been published in peer-review form, or directly replicated. Despite limited empirical examination, dumbfounding has been widely discussed in moral psychology. The present research examines the reliability with which dumbfounding can be elicited, and aims to identify measureable indicators of dumbfounding. Study 1 aimed at establishing the effect that is reported in the literature. Participants read four scenarios and judged the actions described. An Interviewer challenged participants’ stated reasons for judgements. Dumbfounding was evoked, as measured by two indicators, admissions of not having reasons (17%), unsupported declarations (9%) with differences between scenarios. Study 2 measured dumbfounding as the selecting of an unsupported declaration as part of a computerised task. We observed high rates of dumbfounding across all scenarios. Studies 3a (college sample) and 3b (MTurk sample), addressing limitations in Study 2, replaced the unsupported declaration with an admission of having no reason, and included open-ended responses that were coded for unsupported declarations. As predicted, lower rates of dumbfounding were observed (3a 20%; 3b 16%; or 3a 32%; 3b 24% including unsupported declarations in open-ended responses). Two measures provided evidence for dumbfounding across three studies; rates varied with task type (interview/computer task), and with the particular measure being employed (admissions of not having reasons/unsupported declarations). Possible cognitive processes underlying dumbfounding and limitations of methodologies used are discussed as a means to account for this variability.
Keywords: Morality, Dumbfounding, Judgement, Intuitions, Reasoning
Abstract: Moral dumbfounding is defined as maintaining a moral judgement, without supporting reasons. The most cited demonstration of dumbfounding does not identify a specific measure of dumbfounding and has not been published in peer-review form, or directly replicated. Despite limited empirical examination, dumbfounding has been widely discussed in moral psychology. The present research examines the reliability with which dumbfounding can be elicited, and aims to identify measureable indicators of dumbfounding. Study 1 aimed at establishing the effect that is reported in the literature. Participants read four scenarios and judged the actions described. An Interviewer challenged participants’ stated reasons for judgements. Dumbfounding was evoked, as measured by two indicators, admissions of not having reasons (17%), unsupported declarations (9%) with differences between scenarios. Study 2 measured dumbfounding as the selecting of an unsupported declaration as part of a computerised task. We observed high rates of dumbfounding across all scenarios. Studies 3a (college sample) and 3b (MTurk sample), addressing limitations in Study 2, replaced the unsupported declaration with an admission of having no reason, and included open-ended responses that were coded for unsupported declarations. As predicted, lower rates of dumbfounding were observed (3a 20%; 3b 16%; or 3a 32%; 3b 24% including unsupported declarations in open-ended responses). Two measures provided evidence for dumbfounding across three studies; rates varied with task type (interview/computer task), and with the particular measure being employed (admissions of not having reasons/unsupported declarations). Possible cognitive processes underlying dumbfounding and limitations of methodologies used are discussed as a means to account for this variability.
Keywords: Morality, Dumbfounding, Judgement, Intuitions, Reasoning
Are the Neural Correlates of Consciousness in the Front or in the Back of the Cerebral Cortex? Clinical and Neuroimaging Evidence
Are the Neural Correlates of Consciousness in the Front or in the Back of the Cerebral Cortex? Clinical and Neuroimaging Evidence. Melanie Boly, Marcello Massimini, Naotsugu Tsuchiya, Bradley R. Postle, Christof Koch and Giulio Tononi. Journal of Neuroscience Oct 04 2017, 37 (40) 9603-9613; DOI: https://doi.org/10.1523/JNEUROSCI.3218-16.2017
Abstract: The role of the frontal cortex in consciousness remains a matter of debate. In this Perspective, we will critically review the clinical and neuroimaging evidence for the involvement of the front versus the back of the cortex in specifying conscious contents and discuss promising research avenues.
My commentary: Seems to be in the back.
Abstract: The role of the frontal cortex in consciousness remains a matter of debate. In this Perspective, we will critically review the clinical and neuroimaging evidence for the involvement of the front versus the back of the cortex in specifying conscious contents and discuss promising research avenues.
My commentary: Seems to be in the back.
The Effect of an Interruption on Risk Decisions -- Interruptions decrease the novelty of the risk decision and increases its taking
The Effect of an Interruption on Risk Decisions. Daniella Kupor, Wendy Liu and On Amir. Journal of Consumer Research, ucx092, https://doi.org/10.1093/jcr/ucx092
Abstract: Interruptions during consumer decision making are ubiquitous. In seven studies, we examine the consequences of a brief interruption during a financial risk decision. We identify a fundamental feature inherent in an interruption's temporal structure - a repeat exposure to the decision stimuli - and find that this re-exposure reduces decision stimuli's subjective novelty. This reduced novelty in turn reduces decision makers' apprehension and increases the amount of risk that they take in a wide range of financial risky decision contexts. Consistent with our theoretical framework, this interruption effect disappears when a stimulus's subjective novelty is restored after an interruption. We further find that these consequences are unique to interruptions and do not result from other interventions (e.g., time pressure and elongated thinking); this is because an interruption's unique temporal structure (which results in a repeat exposure to the decision stimuli) underlies its consequences. Our findings shed light on how and when interruptions during decision making can influence risk taking.
Keywords: risk taking, decision making, interruption
Abstract: Interruptions during consumer decision making are ubiquitous. In seven studies, we examine the consequences of a brief interruption during a financial risk decision. We identify a fundamental feature inherent in an interruption's temporal structure - a repeat exposure to the decision stimuli - and find that this re-exposure reduces decision stimuli's subjective novelty. This reduced novelty in turn reduces decision makers' apprehension and increases the amount of risk that they take in a wide range of financial risky decision contexts. Consistent with our theoretical framework, this interruption effect disappears when a stimulus's subjective novelty is restored after an interruption. We further find that these consequences are unique to interruptions and do not result from other interventions (e.g., time pressure and elongated thinking); this is because an interruption's unique temporal structure (which results in a repeat exposure to the decision stimuli) underlies its consequences. Our findings shed light on how and when interruptions during decision making can influence risk taking.
Keywords: risk taking, decision making, interruption
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