Tuesday, March 16, 2021

There is a large disconnect between what people believe and what they will share on social media, and this is largely driven by inattention rather than by purposeful sharing of misinformation

The Psychology of Fake News. Gordon Pennycook, David G. Rand. Trends in Cognitive Sciences, March 15 2021. https://doi.org/10.1016/j.tics.2021.02.007

Highlights

Recent evidence contradicts the common narrative that partisanship and politically motivated reasoning explain why people fall for 'fake news'.

Poor truth discernment is linked to a lack of careful reasoning and relevant knowledge, as well as to the use of familiarity and source heuristics.

There is also a large disconnect between what people believe and what they will share on social media, and this is largely driven by inattention rather than by purposeful sharing of misinformation.

Effective interventions can nudge social media users to think about accuracy, and can leverage crowdsourced veracity ratings to improve social media ranking algorithms.


Abstract: We synthesize a burgeoning literature investigating why people believe and share false or highly misleading news online. Contrary to a common narrative whereby politics drives susceptibility to fake news, people are ‘better’ at discerning truth from falsehood (despite greater overall belief) when evaluating politically concordant news. Instead, poor truth discernment is associated with lack of careful reasoning and relevant knowledge, and the use of heuristics such as familiarity. Furthermore, there is a substantial disconnect between what people believe and what they share on social media. This dissociation is largely driven by inattention, more so than by purposeful sharing of misinformation. Thus, interventions can successfully nudge social media users to focus more on accuracy. Crowdsourced veracity ratings can also be leveraged to improve social media ranking algorithms.

Keywords: fake newsmisinformationsocial medianews mediamotivated reasoningdual process theorycrowdsourcingattentioninformation sharing

What Can Be Done? Interventions To Fight Fake News

We now turn to the implications of these findings for interventions intended to decrease the spread and impact of online misinformation.

Current Approaches for Fighting Misinformation

As social media companies are, first and foremost, technology companies, a common approach is the automated detection of problematic news via machine learning, natural language processing, and network analysis [74.75.76.]. Content classified as problematic is then down-ranked by the ranking algorithm such that users are less likely to see it. However, creating an effective misinformation classifier faces two fundamental challenges. First, truth is not a black-and-white, clearly defined property: even professional fact-checkers often disagree on how exactly to classify content [77,78]. Thus, it is difficult to decide what content and features should be included in training sets, and artificial intelligence approaches run the risk of false positives and, therefore, of unjustified censorship [79]. Second, there is the problem of nonstationarity: misinformation content tends to evolve rapidly, and therefore the features which are effective at identifying misinformation today may not be effective tomorrow. Consider, for example, the rise of COVID-19 misinformation in 2020 – classifiers trained to detect largely political content were likely unequipped to be effective for novel false and misleading claims relating to health.

Another commonly used approach involves attaching warnings to content that professional fact-checkers have found to be false (reviewed in [80,81]). A great deal of evidence indicates that corrections and warnings do successfully reduce misperceptions [41,81.82.83.] and sharing [49,84,85]. Despite some early evidence that correction checking could backfire and increase belief in false content [86], recent work has shown that these backfire effects are extremely uncommon and are not a cause for serious concern [87,88].

There are, however, other reasons to be cautious about the sufficiency of professional fact-checking. Most importantly, fact-checking is simply not scalable – it typically requires substantial time and effort to investigate whether a particular claim is false or misleading. Thus, many (if not most) false claims never get fact-checked. Even for those claims that do eventually get flagged, the process is often slow, such that warnings are likely to be absent during the claim's period of peak viral spreading. Furthermore, warnings are typically only attached to blatantly false news, and not to extremely misleading or biased coverage of events that actually occurred. In addition to straightforwardly undermining the reach of fact-checks, this sparse application of warnings could lead to an 'implied truth' effect where users may assume that (false or misleading) headlines without warnings have actually been verified [84]. Fact-checks often also fail to reach their intended audience [89], and may fade over time [90], provide incomplete protection against familiarity effects [49], and cause corrected users to subsequently share more low-quality and partisan content [91].

Another potential approach that is commonly referenced is emphasizing the publishers of news articles, seeking to leverage the reliance on source cues described earlier. This, in theory, could be effective because people (at least in the USA) are actually fairly good at distinguishing between low- and high-quality publishers [92]. However, experimental evidence on emphasizing news publishers is not very encouraging: Numerous studies find that making source information more salient (or removing it entirely) has little impact on whether people judge headlines to be accurate or inaccurate [37,93.94.95.96.97.] (although see [98,99]).

New Approaches for Fighting Misinformation

One potentially promising alternative class of interventions involve a more proactive 'inoculation' or 'prebunking' against misinformation [8,100]. For example, the 'Bad News Game' uses a 10–20 minute interactive tutorial to teach people how to identify fake news in an engaging way [101]. An important limitation of such approaches is that they are 'opt in' – that is, people have to actively choose to engage with the inoculation technique (often for a fairly substantial amount of time – at least in terms of the internet attention span [102]). This is particularly problematic given that those most in need of 'inoculation' against misinformation (e.g., people who are low on cognitive reflection) may be the least likely to seek out and participate in lengthy inoculations. Lighter-touch forms of inoculation that simply present people with information that helps them to identify misinformation (e.g., in the context of climate change [103]) may be more scalable. For example, presenting a simple list of 12 digital media literacy tips improved people's capacity to discern between true and false news in the USA and India [104].

Both fact-checking and inoculation approaches are fundamentally directed toward improving people's underlying knowledge or skills. However, as noted earlier, recent evidence indicates that misinformation may spread on social media not only because people are confused or lack the competency to recognize fake news, but also (or even mostly) because people fail to consider accuracy at all when they make choices about what to share online [21,44]. In addition, as mentioned, people who are more intuitive tend to be worse at distinguishing between true and false news content, both in terms of belief (Figure 1A) and sharing [35,71]. This work suggests that interventions aimed at getting people to slow down and reflect about the accuracy of what they see on social media may be effective in slowing the spread of misinformation.

Indeed, recent research shows that a simple accuracy prompt – specifically, having participants rate the accuracy of a single politically neutral headline (ostensibly as part of a pretest) before making judgments about social media sharing – improves the extent to which people discern between true and false news content when deciding what to share online in survey experiments [21,44]. This approach has also been successfully deployed in a large-scale field experiment on Twitter, in which messages asking users to rate the accuracy of a politically neutral news headline were sent to thousands of accounts who recently shared links to misinformation sites [21]. This subtle prompt significantly increased the quality of the new they subsequently shared (Figure 2B). Furthermore, survey experiments have shown that asking participants to explain how they know whether a headline is true or false before sharing it increases sharing discernment [105], and having participants rate accuracy at the time of encoding protects against familiarity effects [106]. Relatedly, metacognitive prompts – probing questions that make people reflect – increases resistance to inaccurate information [107].

A major advantage of such accuracy prompts is that they are readily scalable. There are many ways that social media companies, or other interested parties such as governments or civil society organizations, could shift people's attention to accuracy (e.g., through ads, by asking about the accuracy of content that is shared, or via public service announcements, etc.). In addition to scalability, accuracy prompts also have the normative advantage of not relying on a centralized arbiter to determine truth versus falsehood. Instead, they leverage users' own (often latent) ability to make such determinations themselves, preserving user autonomy. Naturally, this will not be effective for everyone all of the time, but it could have a positive effective in the aggregate as one of the various tools used to combat misinformation.

Finally, platforms could also harness the power of human reasoning and the 'wisdom of crowds' to improve the performance of machine-learning approaches. While professional fact-checking is not easily scalable, it is much more tractable for platforms to have large numbers of non-experts rate news content. Despite potential concerns about political bias or lack of knowledge, recent work has found high agreement between layperson crowds and fact-checkers when evaluating the trustworthiness of news publishers: the average Democrat, Republican, and fact-checker all gave fake news and hyperpartisan sites very low trust ratings [92] (Figure 3A). This remained true even when layperson raters were told that their responses would influence social media ranking algorithms, creating an incentive to 'game the system' [108]. However, these studies also revealed a weakness of publisher-based crowd ratings: familiarity with a publisher was necessary (although not sufficient) for trust, meaning that new or niche publishers are unfairly punished by such a rating scheme. One solution to this problem is to have laypeople rate the accuracy of individual articles or headlines (rather than publishers), and to then aggregate these item-level ratings to create average scores for each publisher (Figure 3B). Furthermore, the layperson ratings of the articles themselves are also useful. Analyzing a set of headlines flagged for fact-checking by an internal Facebook algorithm found that the average layperson accuracy rating for fairly small crowds correlated equally well with that of professional fact-checkers as the fact-checkers correlated with each other [77]. Thus, using crowdsourcing to add a 'human in the loop' element to misinformation detection algorithms is promising.

These observations about the utility of layperson ratings have a strong synergy with the aforementioned idea of prompts that shift users' attention to accuracy: periodically asking social media users to rate the accuracy of random headlines both (i) shifts attention to accuracy and thus induces the users to be more discerning in their subsequent sharing, and (ii) generates useful ratings to help inform ranking algorithms.

Despite generous Danish social policies, more advantaged families are better able to access, utilize, & influence universally available programs; & purposive sorting by levels of family advantage create neighborhood effects

Lessons from Denmark about Inequality and Social Mobility. James J. Heckman & Rasmus Landersø. NBER Working Paper 28543, March 2021. DOI 10.3386/w28543

Abstract: Many American policy analysts point to Denmark as a model welfare state with low levels of income inequality and high levels of income mobility across generations. It has in place many social policies now advocated for adoption in the U.S. Despite generous Danish social policies, family influence on important child outcomes in Denmark is about as strong as it is in the United States. More advantaged families are better able to access, utilize, and influence universally available programs. Purposive sorting by levels of family advantage create neighborhood effects. Powerful forces not easily mitigated by Danish-style welfare state programs operate in both countries.


Controlling and drinking behaviour and partners’ unemployment status were identified as important factors for married women experiencing intimate partner violence

Mapping of Intimate Partner Violence: Evidence From a National Population Survey. Muluken Dessalegn Muluneh et al. Journal of Interpersonal Violence, March 8, 2021. https://doi.org/10.1177/0886260521997954

Abstract: Evidence on the relative importance of geographical distribution and associated factors with intimate partner violence (IPV) can inform regional and national health programs on women’s health. Four thousand seven hundred and twenty married women aged 15-49 years were interviewed in 2016 about IPV and this data was extracted from the Ethiopian Demographic Health Survey (EDHS) in 2020. The sample was selected by a two-staged cluster survey of women. The analysis was conducted using logistic regression that adjusted for clustering and sampling weights. Moreover, weighted proportions of IPV were exported to ArcGIS to conduct autocorrelations to assess the clustering of IPV. Amongst the 4469 married women who were 15 to 49 years of age included in the analysis, 34% (95% CI, 31.4%-36.3%) experienced IPV, 23.5% ( 95% CI, 21.5%-25.7%) experienced physical violence, 10.1% (95% CI, 8.7%- 11.7 %) experienced sexual violence and 24% (95% CI, 21.7%-26.4 %) experienced emotional violence. Partners’ controlling behaviour [AOR: 3.94; 95% CI, 3.03- 5.12], partner’s alcohol consumption [AOR: 2.59; 95% CI, 1.80- 3.71], partner educational qualifications [AOR: 2.16; 95% CI, 1.26- 3.71], a woman birthing more than five children [AOR: 1.70; 95% CI, 1.12- 2.56] and a history of the woman’s father being physically violent towards her mother [AOR: 1.99; 95% CI, 1.52- 2.59] were associated with an increased risk of IPV amongst married women in Ethiopia. Western and Central Oromia, Western Amhara, Gambella and Central Tigray and Hararri were identified as hot spot areas in Ethiopia (p<0.001). In this study, there was a significant geographic clustering of IPV in Ethiopia. Controlling and drinking behaviour and partners’ unemployment status were identified as important factors for married women experiencing IPV. Hence, there is a need for a context- driven evidence-based design intervention to reduce the impact of IPV.


Keywords: domestic violence, sexual assault, cultural contexts, alcohol and drugs, assessment, female offenders



Monday, March 15, 2021

CEO Stress, Aging, and Death

CEO Stress, Aging, and Death. Mark Borgschulte, Marius Guenzel, Canyao Liu & Ulrike Malmendier. NBER Working Paper 28550. DOI 10.3386/w28550

Abstract: We estimate the long-term effects of experiencing high levels of job demands on the mortality and aging of CEOs. The estimation exploits variation in takeover protection and industry crises. First, using hand-collected data on the dates of birth and death for 1,605 CEOs of large, publicly-listed U.S. firms, we estimate the resulting changes in mortality. The hazard estimates indicate that CEOs’ lifespan increases by two years when insulated from market discipline via anti-takeover laws, and decreases by 1.5 years in response to an industry-wide downturn. Second, we apply neural-network based machine-learning techniques to assess visible signs of aging in pictures of CEOs. We estimate that exposure to a distress shock during the Great Recession increases CEOs’ apparent age by one year over the next decade. Our findings imply significant health costs of managerial stress, also relative to known health risks.


Human energy increases continuously during the weekend, drops on Monday, follows a passageway trajectory from Monday to Thursday, and increases on Friday again; increases in sleep quality prediced energy changes

Continuity in transition –Combining recovery and day‐of‐week perspectives to understand changes in employee energy across the seven‐day week. Oliver Weigelt  Katja Siestrup  Roman Prem. Journal of Organizational Behavior, March 14 2021. https://doi.org/10.1002/job.2514

Summary: We integrate perspectives from research on recovery from work and perspectives from day‐of‐week research to predict continuous as well as discontinuous changes in vitality and fatigue. We examine whether changes in recovery experiences and sleep quality predict changes in human energy over the course of the weekend. Furthermore, we consider positive anticipation of work at the start of the workweek and effort during the workweek to predict changes in energy. We collected experience sampling data from 87 employees over the course of twelve days. In total, 2187 observations nested in 972 days were eligible for analysis. Applying discontinuous growth curve modeling, we found that human energy increases continuously during the weekend, drops on Monday, follows a passageway trajectory from Monday to Thursday, and increases on Friday again. Changes in recovery experiences did not predict changes in energy, increases in sleep quality did. Positive anticipation of work attenuated the drop in vitality on Monday. Effort did not predict changes in energy over the course of the workweek. Our results suggest that the transition between weekends and workweeks and vice versa accounts for considerable changes in human energy and that weekends are recuperative, particularly because they provide the opportunity for better sleep.


Sexual violence in college men: Some predictors are Hostile Masculinity, Impersonal Sex, lower empathy, peer support, extreme pornography use, and participation in alcohol parties

Factors predictive of sexual violence: Testing the four pillars of the Confluence Model in a large diverse sample of college men. Neil M. Malamuth  Raina V. Lamade  Mary P. Koss  Elise Lopez  Christopher Seaman  Robert Prentky. Aggressive Behavior, March 14 2021. https://doi.org/10.1002/ab.21960

Abstract: This article focuses on the characteristics of sexually violent men who have not been convicted of a crime. The objective of this study was to test the four key interrelated pillars of the Confluence Model. The first key pillar posits the interaction of Hostile Masculinity and Impersonal Sex as core risk predictors. The second pillar entails a “mediated structure” wherein the impact of more general risk factors is mediated via those specific to aggression against women. The third pillar comprises a single latent factor underlying various types of sexual violence. The fourth pillar expands the core model by including the secondary risk factors of lower empathy, peer support, extreme pornography use, and participation in alcohol parties. An ethnically diverse sample of 1,148 male students from 13 U.S. colleges and universities completed a comprehensive survey that assessed the hypothesized risk factors and self‐reported sexual violence, which included noncontact sexual offenses, contact sexual coercion, and contact sexual aggression. A series of multiple regression analyses were conducted before testing structural equation models. The results supported the integration of the four pillars within a single expanded empirical model that accounted for 49% of the variance of sexual violence. This study yielded data supporting all four key pillars. These findings provide information about non‐redudant risk factors that can be used to develop screening tools, group‐based and individually tailored psychoeducational and treatment interventions.

Check also An Evolutionary Perspective on Sexual Assault and Implications for Interventions. Mark Huppin, Neil M. Malamuth, Daniel Linz. In the Handbook of Sexual Assault and Sexual Assault Prevention pp 17-44, October 19 2019. https://www.bipartisanalliance.com/2019/11/an-evolutionary-perspective-on-sexual.html


Spending money on pets promotes happiness

Give a dog a bone: Spending money on pets promotes happiness. Michael W. White, Nazia Khan, Jennifer S. Deren, Jessica J. Sim & Elizabeth A. Majka. The Journal of Positive Psychology, Mar 13 2021, https://doi.org/10.1080/17439760.2021.1897871

Abstract: Pet owners routinely spend money on services, accessories, and gifts for their pets. The present research investigates the affective consequences of pet spending. Specifically, we propose that spending money on pets promotes happiness. As predicted, a lab study demonstrated that pet owners who were randomly assigned to recall a time they spent money on their pet reported greater happiness than those who recalled spending money on themselves. Likewise, a field study demonstrated that pet owners who were randomly assigned to spend $5 on their pet reported greater happiness than those who were assigned to spend on themselves or another person – an effect specific to feelings of happiness rather than to mood more generally. This research offers pet owners an evidence-based strategy for boosting happiness, representing an additional intentional activity that can be used to improve well-being.

KEYWORDS: Happinesspetsmoneywell-being


Sunday, March 14, 2021

Surgent, dominant, and athletic men could possess a greater ability to regulate oxidative stress; women whose faces were judged as more attractive also had higher oxidative stress, a possible cost of maintaining this phenotype

Oxidative stress and the differential expression of traits associated with mating effort in humans. Nicholas M. Grebe et al. Evolution and Human Behavior, March 13 2021. https://doi.org/10.1016/j.evolhumbehav.2021.02.007

Abstract: Oxidative stress is a physiological condition in which reactive oxygen species created through cellular respiration can potentially damage DNA and tissue. Oxidative stress may partially mediate trade-offs between reproductive effort and survival efforts. On the one hand, traits associated with reproductive effort, particularly costly male-male competition, are expected to raise oxidative stress. On the other hand, behavioral strategies may be a critical mediating mechanism, such that those who can better resist the physiological costs of oxidative damage exhibit increased mating effort. In a sample of 248 college students (173 men), we examined the associations between traits linked to mating effort—including personality features, athleticism, and history of illness—with levels of 8-OHdG, a biomarker of oxidative stress. 8-OHdG was measured twice, one week apart, once during active hours and once at awakening. In men, surgency, social dominance, and athleticism were all negatively associated with 8-OHdG levels in awakening, but not lab samples collected during active hours. In women, these same traits were positively associated with 8-OHdG levels, particularly in morning samples. Differences in associations based on sex and time of collection introduce additional complexities to understanding links between oxidative stress and mating effort.

Keywords: Oxidative stressMating effortHuman biologyPersonality

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4. Discussion

4.1 Summary of Associations

Our study explored two alternative scenarios for associations between oxidative stress and putative measures of investment in mating effort. On one hand, surgent, dominant, and athletic men could possess a greater ability to regulate oxidative stress, reflected by lower levels of 8-OHdG, consistent with associations found in rhesus macaques (Georgiev et al., 2015); on the other hand, high activity levels of these men could produce associations in the opposite direction. As a comparison, we investigated these same features in women, predicting weaker or absent associations. Our results showed that surgent, dominant, and athletic men tended to produce low levels of 8-OHdG in first-of-the-morning urine. Provisionally, we interpret this pattern to have one or both of two explanations. First, surgent, dominant, and athletic men may experience relatively little oxidative damage throughout the day to be repaired. Second, surgent, dominant, and athletic men may experience relatively little oxidative damage as a function of basal metabolic processes experienced overnight. In turn, these associations may be attributable to multiple underlying processes, including a smaller number of ROS-producing mutations and/or relatively low levels of environmental toxins. In either of these scenarios, men’s surgency, dominance, and athleticism partly reflects underlying condition—fundamentally, the capacity to efficiently convert energy into fitness-enhancing activity. An explanation for these associations may lie in the role of oxidative stress in the production of sexually selected signals. Individuals who suffer lower costs to energy production in the form of oxidative stress will be selected to energetically invest, over development, more heavily in capacities resulting in surgency, social dominance, and athleticism.

By contrast, women’s surgency, social dominance, and athleticism positively covaried with levels of 8-OHdG measured in urine collected at awakening. Why do women show a very different pattern? The pattern for men in the scenarios above results from selection for investment in traits (i.e., surgency, dominance, and athleticism) that may boost mating success in men that can physiologically “afford” them due to efficient oxidative stress regulation. To some degree, despite sex differences, women may have ancestrally benefited from investments in developing these phenotypes, too. At the same time, there is reason to suspect that these investments would not have been contingent on condition in the same way we propose they would have been for men. If women who possess relatively high levels of surgency, dominance, and athleticism are not ones who pay low costs for energy production in the form of oxidative stress, there is no reason to expect negative associations between them and oxidative stress. And indeed, because these traits—and many others that reflect increased mating effort—may be associated with higher levels of energy production, one might expect that women who possess them generate greater levels of ROS, which would result in greater oxidative damage and greater need for repair. One recent study presents evidence consistent with this notion: women whose faces were judged as more attractive also had higher oxidative stress, suggesting a possible cost of maintaining this phenotype (Marcinkowska et al., 2020). (By contrast, Gangestad et al. [2010] found male facial attractiveness to covary positively with a biomarker of oxidative stress; Foo et al. [2017] did not detect an association for either sex.)

We emphasize that these interpretations are provisional and require corroboration, both via direct replication, and via extensions that collect additional phenotypic information pertaining to mating effort (e.g., anthropometric measurements). We offer them because they may lead to fruitful directions for future research At the same time, in light of the complexities of associations between sexual signals, reproductive effort, and oxidative stress, some of which we reviewed in the introduction, we fully recognize that alternative explanations are possible. Furthermore, consistent with the notion that there is still much to be resolved in this literature, we also find unexpected, major differences in patterns based on when and how oxidative stress biomarkers are sampled, which we discuss below.


4.2 Implications for Understanding the Moderating Effect of Collection Time

Strong sex-specific associations between personality/health and oxidative stress were qualified by time of sampling. For men, negative associations of surgency, social dominance, and athleticism with levels of 8-OHdG measured in awakening samples disappeared when examining samples collected during lab sessions later in the day. Surgent, dominant, and athletic women had relatively high levels of 8-OHdG in both awakening and active samples, though associations were weaker in the latter set of samples.

One can reasonably ask whether these moderation effects are robust and meaningful. There are several reasons to think that they are. First, moderation by sex and sample was significant and consistent across three related factors (surgency, dominance, athleticism). Second, in analyses that substituted time since awakening for the crude binary of “sampling session”, moderation effects consistently strengthened, supporting the interpretation that this is the relevant difference driving effects. Third, our results remained similar in analyses predicting log-transformed 8-OHdG concentrations, suggesting outliers were not responsible for our observed pattern of effects. Finally, we observed a similar moderation effect for uric acid: effects differed between awakening and lab sessions (though, in this instance, this interaction was not moderated by sex). This effect of uric acid was independent from the effects of surgency, dominance, and athleticism. Nonetheless, the fact that time since awakening moderated this effect too bolsters the idea that time of sampling importantly moderates associations with 8-OHdG. While further studies are needed to establish the robustness and generalizability of these moderation effects, below we offer our provisional interpretation of what they might reflect in our studies.

Concentrations of 8-OHdG in urine do not capture instantaneous levels. Rather, they reflect the accumulation of 8-OHdG filtered out of circulating blood by the kidneys and stored in the bladder between last void and current void. For a first-morning void, this time span consists of a long, inactive period—sleep. By contrast, urine collected during daytime hours has largely accumulated during relatively short, active periods. Based on this observation, perhaps the most straightforward explanation for diverging associations is that an awakening measure of oxidative stress represents a more stable, and thus desirable, estimate of accumulated damage compared to daytime samples more affected by metabolic demands of daily activities (e.g., exercise). The fact that medical biomarker research favors first-morning voids for similar reasons (e.g. Witte et al., 2009; Heerspink et al., 2010) supports this interpretation.

We do entertain a second interpretation that specifically implicates sleep. Much somatic repair occurs during sleep, and indeed, one primary function of sleep across a wide range of taxa may be to permit allocation of energy to repair processes for oxidative damage (Anafi et al., 2013). At the same time, sleep itself slows the accumulation of oxidative damage, as the rate of metabolic expenditure slows. From this reasoning, it follows that someone with relatively low levels of 8-OHdG accumulated during sleep (i.e., found in first-morning voids) (a) experiences relatively low levels of oxidative damage throughout the day, to be repaired at night, and/or (b) produces relatively low levels of oxidative damage through basal metabolic processes. This interpretation is provisional and requires additional tests. We did not detect effects of sleep quality in our sample but future research may further investigate its impact.


4.2.1 Associations with Uric Acid

Because oxidative stress can be affected by the action of anti-oxidants, we considered whether concentrations of uric acid influenced the relationships we examined. While we did not find that uric acid mediated links between 8-OHdG and the traits we examined, we did find that uric acid covaried with 8-OHdG differently in awakening and active daytime samples, providing an independent piece of evidence that time of sampling affects associations with 8-OHdG. The effects of uric acid on oxidative damage can reverse, from anti-oxidant to pro-oxidant, in response to cellular environments (Sautin et al., 2007; So & Thorens, 2010), and prior evidence suggests that circadian rhythms have a strong influence on these roles (Stringari et al., 2015; Kono et al., 2010). Our examination of the role of anti-oxidants was limited in this study. Future research would benefit from considering a wider range of anti-oxidant assays, which can provide a triangulated estimate of different components underlying an organism’s anti-oxidant system (Constantini, 2011).


4.3 No Detected Associations with Susceptibility to Infectious Disease

In contrast to individual differences in surgency, social dominance, and athleticism, susceptibility to infectious disease did not substantially covary in our study with 8-OHdG, either in men or women, or in awakening or lab samples. Future research may examine these associations further, as well as assess associations between current infectious status and 8-OHdG levels. We note here that our results are based on two samples of young adults from a non-clinical, industrialized population. This poses a constraint on generalization for all of the conclusions we have presented, but it may be particularly relevant for measures of susceptibility to infectious disease. Clinical populations, unsurprisingly, have an elevated susceptibility to infectious disease (WHO, 2011), and distributions of immune function biomarkers and disease susceptibility differ markedly between industrialized and non-industrialized populations, which has important consequences for patterns of energetic investment (e.g. Blackwell et al., 2016). A broader sampling of the range of infectious disease burden in future research will permit a fuller examination of its role in oxidative stress and energetic trade-offs.


2D:4D Digit Ratios in Adults with Gender Dysphoria: A Comparison to Their Unaffected Same-Sex Heterosexual Siblings, Cisgender Heterosexual Men, and Cisgender Heterosexual Women

2D:4D Digit Ratios in Adults with Gender Dysphoria: A Comparison to Their Unaffected Same-Sex Heterosexual Siblings, Cisgender Heterosexual Men, and Cisgender Heterosexual Women. Şenol Turan, Murat Boysan, Mahmut Cem Tarakçıoğlu, Tarık Sağlam, Ahmet Yassa, Hasan Bakay, Ömer Faruk Demirel & Musa Tosun. Archives of Sexual Behavior, Mar 10 2021, https://link.springer.com/article/10.1007%2Fs10508-021-01938-5

Abstract: We compared gender dysphoria (GD) patients and their same-sex siblings in terms of their 2D:4D ratios, which may reflect prenatal exposure to androgen, one of the possible etiological mechanisms underlying GD. Sixty-eight GD patients (46 Female-to-Male [FtM]; 22 Male-to-Female [MtF]), 68 siblings (46 sisters of FtMs; 22 brothers of MtFs), and 118 heterosexual controls (62 female; 56 male) were included in the study. FtMs were gynephilic and MtFs were androphilic. We found that 2D:4D ratios in the both right hand (p < .001) and the left hand (p = .003) were lower in male controls than in female controls. Regarding right hands, FtM GD patients had lower 2D:4D ratios than female controls (p < .001) but their ratios did not differ from those of their sisters or male controls. FtM GD patients had no significant difference in their left-hand 2D:4D ratios compared to their sisters or female and male controls. While there was no significant difference in right hands between FtM's sisters and male controls, left-hand 2D:4D ratios were significantly higher in FtM's sisters (p = .017). MtF GD patients had lower right-hand 2D:4D ratios than female controls (p <.001), but their right-hand ratios did not differ from those of their brothers and male controls. There was no significant difference in left-hand 2D:4D ratios between MtF GD patients, and their brothers, or female and male controls. FtM GD patients showed significantly masculinized right-hand 2D:4D ratios, while there was no evidence of feminization in MtF GD patients.

Discussion

The 2D:4D ratio is thought to be determined during critical periods of prenatal development under the influence of sex hormones. Here, we conducted a case-control study of the 2D:4D ratio, which is thought to be indicative of prenatal exposure to sex hormones, in patients with GD, their unaffected same-sex heterosexual siblings, and cisgender heterosexual male and female controls. We observed that patients with FtM GD had lower right-hand 2D:4D ratios than cisgender heterosexual female controls and they did not significantly differ from cisgender heterosexual male controls. Although they had lower right-hand 2D:4D ratios than their unaffected heterosexual sisters, the difference was not significant. Furthermore, the left-hand 2D:4D ratios in patients with FtM GD did not differ significantly from that of their unaffected heterosexual sisters, cisgender heterosexual male or female controls. Patients with MtF GD had lower right-hand 2D:4D ratios than cisgender heterosexual female controls but they did not show a significant difference from their unaffected heterosexual brothers or cisgender heterosexual male controls. There was no significant difference in the left-hand 2D:4D ratios between patients with MtF GD and their unaffected heterosexual brothers, as well as the cisgender heterosexual male or cisgender heterosexual male controls.

Early studies of 2D:4D ratios in patients with GD found that patients with MtF GD have higher right-hand 2D:4D ratios than those of male controls, while differences in 2D:4D ratios between patients with FtM GD and female controls were not significant (Kraemer et al., 2007; Schneider et al., 2006). However, subsequent studies found results contradicting with the findings of these two first studies. Wallien et al. (2008) found a lower 2D:4D ratio in patients with FtM GD in comparison with female controls, but no significant difference between patients with MtF GD and male controls. Vujovic et al. (2014) echoed and extended the finding reported by Hisasue et al. (2012) that patients with FtM GD had the lowest left-hand 2D:4D ratios, as measured by X-rays, in comparison with both male and female controls. In a similar vein, Leinung and Wu (2017) found a low dominant-hand 2D:4D ratio in patients with FtM GD compared to female controls; however, a feminized 2D:4D (higher) in patients with MtF GD in comparison with male controls was not observed. In another more recent study, Sağlam et al. (2020) found a lower right-hand 2D:4D ratio in patients with FtM GD in comparison with female controls, but no significant difference between patients with MtF GD and male controls in both hands. In a meta-analytic study, Voracek, Kaden, Kossmeier, Pietschnig, and Tran (2018) concluded that patients with MtF GD showed feminized right-hand 2D:4D digit ratios, while the identical effect for the left-hand digit ratio was not significant. However, the study findings underscored that patients with FtM GD had neither masculinized right-hand 2D:4D ratios nor left-hand 2D:4D digit ratios. In another meta-analytic study conducted by Sadr et al. (2020), it was shown that 2D:4D digit ratios of patients with MtF GD (transwomen) were higher (feminized) than male controls and this finding was consistent across studies and both hands, but the effect sizes were small (left hand: d = .19, p = .010; right hand: d = .29, p = .0009). For patients with FtM GD (transmen), they had a lower (masculinized) 2D:4D digit ratio in both hands than female controls, while it was detected that the effect sizes were not statistically significant (left hand: d = − .20, p = .195; right hand: d = − .36, p = .123). The latest meta-analytic study conducted by Siegmann et al. (2020) showed that the 2D:4D digit ratios of patients with MtF GD were significantly higher than male controls (Hedge’s g = .153), and this effect is even more pronounced if the diagnosis was made by a clinician (Hedge’s g = .193). They did not detect any significant difference between patients with FtM GD and female controls.

In the present study, we found that patients with FtM GD had lower right-hand 2D:4D ratios than cisgender heterosexual female controls, but did not have lower ratios than cisgender heterosexual male controls. Previous studies have concluded that in humans the right-hand 2D:4D ratios are more sensitive to early prenatal androgen exposure than the left 2D:4D ratios (Hönekopp & Watson, 2010; Manning, 2002; Manning, Scutt, Wilson, & Lewis-Jones, 1998; Xu & Zheng, 2015). In keeping with the previous literature (Hönekopp et al., 2010; Kraemer et al., 2007; McFadden et al., 2005; Schneider et al., 2006), the differences appear to be more pronounced in the right-hand 2D:4D ratios in our study. To account for this finding, we may suggest that increased levels of prenatal steroid exposure may be associated with greater lateralization toward the left hemisphere (Grimshaw, Bryden, & Finegan, 1995; Jackson, 2008; Witelson & Nowakowski, 1991) which may make the differences in finger length ratios more visible in the right hand. Thus, ICC analyses showed that the 2D:4D ratios of patients with FtM GD and their unaffected heterosexual sisters revealed moderate resemblance in both the right hand and in the left hand, with a stronger correlation for the right hand. Adding to this perspective, an animal model put forth by Zheng and Cohn (2011) suggested that the 2D:4D ratios of the right paw are more sensitive to prenatal androgen exposure than the 2D:4D ratios of the left paw. Emerging evidence and the consistency of relevant findings appear to give credence to the increased sensitivity of the right hand to prenatal androgen exposure (Schneider et al., 2006). In addition to this, we also found no significant difference in the left-hand 2D:4D ratios between patients with FtM GD and cisgender heterosexual male controls. Vujovic et al. (2014) reported that patients with FtM GD showed the lowest left-hand 2D:4D ratio compared to both the control males and females. These findings may be interpreted as meaning that both the right and left hand may be affected by prenatal androgen exposure to a certain degree, but that this influence may be stronger for the right hand. However, there is no credible explanation for an underlying mechanism that specifies a different association of the right and the left finger lengths with prenatal androgen levels, and thus, the mechanism underlying this needs further investigation (Hisasue et al., 2012).

Growing evidence from family and twin studies demonstrates that genetic factors contribute to the development of GD (Gomez-Gil et al., 2010; Heylens et al., 2012; Polderman et al., 2018; Turan & Demirel, 2017), but a strong candidate gene accounting for the development of GD is yet to be identified (Zucker et al., 2016). In human beings, many traits and diseases have a polygenic architecture (Zucker et al., 2016), and many genotypical characteristics evolve into phenotypical traits through interactions with the environment. GD is most likely a complex condition that results from a combination of multiple genetic and environmental factors. In this context, the term endophenotype, meaning measurable components unseen by the unaided eye along the pathway between disease and genotype, has arisen as an important concept in the investigation of complex psychiatric diseases (Gottesman & Gould, 2003). An endophenotype is a quantitative biological trait which shows greater prevalence in unaffected first-degree parents of GD patients than in the general population ((Flint & Munafo, 2007; Kendler & Neale, 2010) and may be neurophysiological, biochemical, endocrinological, neuroanatomical, cognitive, or neuropsychological in nature (Gottesman & Gould, 2003).

In keeping with the literature, the most salient finding of the current data was that patients with FtM GD’s right-hand 2D:4D ratios had significant and strong intraclass correlation with their unaffected heterosexual sisters’ right 2D:4D ratios (r = 0.55). The same was also true for the left-hand 2D:4D ratios, but with a relatively more modest intraclass correlation coefficient (r = 0.36). In contrast, neither the intraclass correlation coefficients for the right-hand nor the left-hand 2D:4D ratios of patients with MtF GD and their unaffected heterosexual brothers were substantial. Moreover, patients with FtM GD and their unaffected heterosexual sisters did not significantly differ in their right 2D:4D ratios from cisgender heterosexual male controls.

These results may be interpreted as further evidence for significant associations between prenatal testosterone exposure and the gender-related behaviors previously suggested in the literature (Brown, Hines, Fane, & Breedlove, 2002; Grimbos et al., 2010; Hines, 2006; Lutchmaya, Baron-Cohen, Raggatt, Knickmeyer, & Manning, 2004; Voracek, Dressler, & Manning, 2007). To the best of our knowledge, relying on the present results, which were consistent with the preceding data (Manning, Bundred, Newton, & Flanagan, 2003; van Anders, Vernon, & Wilbur, 2006), the right-hand 2D:4D digit ratios, in particular, can be considered an endophenotype for masculinization in biological females, which may result in GD.

In this study, we found that patients with MtF GD had lower right-hand 2D:4D digit ratios than cisgender heterosexual female controls, but the mean difference from cisgender heterosexual female controls for the left-hand digit ratios was not significant. On the other hand, unlike patients with MtF GD, the unaffected heterosexual brothers of MtF GD patients had significantly lower left-hand 2D:4D ratios than cisgender heterosexual female controls. These findings are partly consistent with those of previous studies (Kraemer et al., 2007; Schneider et al., 2006; Vujovic et al., 2014) showing that patients with MtF GD seem to also be affected by prenatal androgen exposure, with the exception of the direction of the hand, in which right-hand sensitivity has been widely highlighted. The masculinization in patients with MtF GD might be conceived of as a “ceiling effect” in which males are exposed to sufficient levels of androgen stimulation during the prenatal period (Breedlove, 2010), and the right hand may be more affected from this exposure. However, the 2D:4D digit ratios did not show an endophenotypic characteristic for patients with MTF, when their unaffected heterosexual siblings, cisgender heterosexual male controls, and cisgender heterosexual female controls were considered.

Our study had several limitations that should be considered. First, the sample sizes were relatively small in all groups, which compromise the generalizability of the current results. Second, the measurement method of finger length was indirect. Previous studies showed that indirect finger length measurement methods such as photocopies tended to produce lower 2D:4D ratios than direct measurements (Manning, Fink, Neave, & Caswell, 2005; Ribeiro, Neave, Morais, & Manning, 2016; Xu & Zheng, 2015). Therefore, it has been suggested that indirect measurements may not be the best method to investigate sex or gender effects in 2D:4D ratios (Manning, 2017). However, it has been argued that indirect measurement methods can be used as long as 2D:4D ratios obtained with different digit measurement methods are combined within one study (Xu & Zheng, 2015). Third, because siblings were recruited by patients with GD, it can be said that we have a biased sample. Finally, the absence of patients with FtM GD who were sexually attracted to men and patients with MtF GD who were sexually attracted to women make it difficult to distinguish the effect of sexual orientation and gender identity on digit ratio. As a matter of fact, in the meta-analysis study conducted by Grimbos et al. (2010), similar to the results of our study, while homosexual women had a lower 2D:4D ratio than did heterosexual women, no significant difference was found between homosexual and heterosexual men.

In conclusion, patients with FtM GD had significantly masculinized right-hand 2D:4D ratios. The unaffected heterosexual sisters of patients with FtM GD measured between the digit ratios of cisgender heterosexual male and females in terms of right-hand 2D:4D ratio. This could be indicative of an endophenotype for prenatal exposure to androgens that has long been considered a significant antecedent of this phenomenon of the right-hand 2D:4D digit ratio. In contrast, we did not find prominent evidence pointing to feminization in the 2D:4D ratio in patients with MtF GD. Patients with MtF GD seemed to follow different developmental pathways in the early period. Further studies with larger samples should be conducted to develop a more sophisticated understanding of the potential underpinnings of GD in relation to the 2D:4D ratio.

Children Show a Gender Gap in Negotiation; let's change children so we can correct this ugly feature

Children Show a Gender Gap in Negotiation. Sophie H. Arnold, Katherine McAuliffe. Psychological Science, January 6, 2021. https://doi.org/10.1177/0956797620965544

Abstract... In the United States, there is an unfortunate yet pervasive gender gap in wages: Women tend to make less than men for doing the same work. One prominent account for why this wage gap exists is that women and men negotiate differently. However, we currently do not know whether differences in negotiation are a product of extensive experience or are deeply rooted in development. Here, we brought data from children to bear on this important question. We gave 240 children between the ages of 4 and 9 years old a chance to negotiate for a bonus with a female or a male evaluator. Boys asked for the same bonus from a male and a female evaluator. Older girls, in contrast, asked for a smaller bonus from a male than a female evaluator. Our findings suggest that a gender gap in negotiation emerges surprisingly early in development, highlighting childhood as a key period for interventions.

Keywords: negotiation, gender, wage gap, social categories, social cognitive development, open data, open materials